Subgroup analysis of 19 clusters where at least one infection occurred during baseline showed 33.3% ( P-value = 0.083) and 40.9% ( P-value = 0.0236, statistically significant at the one-sided 5% significance level) protective effect to first infection and overall infections, respectively. Purportedly, this was due in part to zero to low incidence in some clusters, undermining the ability to detect a protective effect. The 24-cluster protective effect of 27.7% and 31.3%, for time to first-event and overall (total new) infections, respectively, was not statistically significant. Screening detected 164 first-time infections and an accumulative total of 459 infections in 667 subjects in placebo-control households, and 134 first-time and 253 accumulative total infections among 665 subjects in active intervention households. Monthly blood screening and biweekly human-landing mosquito catches were performed during a 10-month baseline (June 2015–March 2016) and a 24-month intervention period (April 2016–April 2018). Following radical cure in 1,341 children aged ≥ 6 months to ≤ 5 years in 24 clusters, households were given transfluthrin or placebo passive emanators (devices designed to release vaporized chemical).
TRINITY BLOOD EPISODE 24 SUB INDO TRIAL
Kevin Baird, Eijkman-Oxford Clinical Research Unit, Oxford University, Jakarta, Indonesia, E-mail: cluster-randomized, double-blinded, placebo-controlled trial was conducted to estimate the protective efficacy (PE) of a spatial repellent (SR) against malaria infection in Sumba, Indonesia. Achee, Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN, E-mails: and J. Eugenio, Department of Applied Mathematics, University of Notre Dame, Notre Dame, IN, E-mails: and Jared Hendrickson, Center for Computer Research, University of Notre Dame, Notre Dame, IN, E-mail: Timothy Burton, Frank Collins, John P. Bangs, Public Health and Malaria Control, PT Freeport Indonesia, International SOS, Kuala Kencana, Papua, Indonesia, E-mail: Claus Bøgh, The Sumba Foundation, Public Health and Malaria Control, Bali, Indonesia, E-mail: Fang Liu and Evercita C. Authors’ addresses: Din Syafruddin, Puji Asih, Ismail Ekoprayitno Rozi, Dendi Hadi Permana, Anggi Puspa Nur Hidayati, Lepa Syahrani, and Siti Zubaidah, Department of Malaria, Eijkman Institute for Molecular Biology, Jakarta, Indonesia, E-mails: and Dian Sidik, Department of Epidemiology, Faculty of Public Health, Universitas Hasanuddin, Makassar, Indonesia, E-mail: Michael J.
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